I'll bite.
We have 2 BES servers and over 7 Exchange servers however our BES servers are setup to communicate with 3 servers only, and here's why.
RIM states that you cannot have have latency over 40ms between BES and Exchange. We have 3 Exchange servers and 2 BES servers in North America. 1 BES handles 2 Exchange servers (Pacific and Mountain) and the other BES does just the East coast. We initially had just 1 BES for all of North America until 6 months ago (roughly) when we were hearing of bad/poor/degraded service for just Eastern users. The pings from our BES to the Exchange server in the east was in the 130+ ms range whereas the pings for our Pacific Exchange server was 15-25ms and the Mountain server was <1ms due to it being in the same office. Once we installed a new BES out east, all our problems went away, nearly instantly.
Our Pacific Exchange server just happens to process email for certain South American countries and they work just fine because the latency is low even if the device isn't close to home.
To get this running, we setup the BES' to share the same SQL database so we can move users from the current BES to the newer BES without having to re-activate those users. It's a great feeling to move a user and have them report that it's working better than it ever did.
For additional info, we have 330+ users on the shared database with one BES handling 2/3's the user load. Our Exchange servers handle email for 4000+ users and are also setup with SP2 so we can get WM5/6 devices to work as well.
Hopefully this helps and I didn't ramble on too long.
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