May I recommend a quick search of the forums for migration. You're asking a pretty general question on migration and it can depend on many factors. Check out some of the set ups on your search results and determine which mirrors your current setup. Then you'll have some specific questions you can pose.
In my case, I ran 4.x from physical servers on Exchange 03 with remote SQL. Spun up both BES and SQL to new VM's and ran the transporter tool. Very easy and very clean.
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I'm actually lost...
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