We have BES 4.0 on Domino and starting seeing stability issues (i.e. crashes in NBES process) at 1350 users. After moving 100 users to new server, the server is more stable. I would say 1200 or even better 1000 as a max per server in the Domino environment.
Even if the server can support it, think about failover. How long would it take to move over 1000 users to another server for DR purposes? There are other considerations than just raw capacity at these higher numbers.
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