There is actually a KB article on the TSupport site that talks about Vista Support and Desktop Manger 4.2 & 4.2.1 but I have yet to see the download available. I have pasted the article for reference below for those of you who do not have a TSupport login.
BlackBerry Desktop Software and Microsoft Windows Vista Known Issues
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Doc ID : KB11323
Last Modified : 2007-01-09
Document Type : What Is
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Environment
BlackBerry® Desktop Software
Microsoft® Windows Vista™
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Details
The following table lists the Known Issues associated with BlackBerry Desktop Software 4.2 and 4.2 Service Pack 1 (4.2.1) using Microsoft Windows Vista.
SDR Definition
109340
BlackBerry Desktop Software installers are not signed.
BlackBerry Desktop software 4.2 - The BlackBerry device user is prompted with the following message before installing the BlackBerry Desktop Software: An unidentified program wants access to your computer dialog appears. The BlackBerry device user must click Allow before installing the BlackBerry Desktop Software.
BlackBerry Desktop software 4.2 Service Pack 1 (4.2.1) - The BlackBerry device user is prompted with the following message before installing the BlackBerry Desktop Software: A program needs your permission to continue. If you started this program, continue. The BlackBerry device user must click Continue before installing the BlackBerry Desktop Software.
111933
A Windows Firewall warning appears when logging into a BlackBerry email account in BlackBerry Desktop Manager.
109696
IBM® Lotus Notes® Login Screen does not display login information in the For User and At Location fields when starting the BlackBerry Desktop Manager for the first time.
108354
Intellisync Help does not open. Two Windows Help and Support windows appear when the BlackBerry device user clicks, BlackBerry Desktop Software > Synchronize > Configuration tab > Configure Sync > Help.
113319
The timezone on the BlackBerry device changes after synchronizing with the BlackBerry Desktop Manager 4.2 Service Pack 1 (4.2.1) on Windows running the Microsoft Outlook® 2007 patch.
104167
The timezone on the BlackBerry device changes after synchronizing with the BlackBerry Desktop Manager 4.2 on Windows Vista.
The following table lists Known Issues resolved with an upgrade to BlackBerry Desktop Software 4.2 Service Pack 1 (4.2.1) using Microsoft Windows Vista.
SDR Definition
109811
Virtual Serial Port (VSP): <VISTA only 32-bit and all 64-bit> Windows stops responding and displays a blue screen if the BlackBerry Desktop Manager is closed while the BlackBerry device is connected.
103475
Application Data directory does not inherit security attributes from parent. BlackBerry device users are unable open the following directory: C:\Users\<user>\AppData\Roaming\Blackberry Desktop\Transaction Manager\ComponentData\TraceLogs
104167
The timezone on the BlackBerry device changes after synchronizing with the BlackBerry Desktop Manager 4.2 on Windows Vista.
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