here is my hit llist on 2008 issues.
BAS wont open on 2008 R2
KB23927-BlackBerry Administration Service continually stops and restarts, after an operating system hotfix is applied
Update for Windows Server 2008 R2 x64 Edition (KB2534366)
"0xC000009A" error message when you try to install Windows 7 SP1 or Windows Server 2008 R2 SP1
change the SQL Server Browser from Disabled to Automatic after windows update ( yes it gets changed)
KB980232 (SMB updates)
its part of a bigger rollup pack (MS10-20).
Uninstall this update, reboot. BES wont work... Windows update again (SQL SP3 et all), reboot. BES will work.
BTW heres how you know you have the problem.
go to start->run cmd.exe
c:\> new view
SYSTEM ERROR 87 HAS OCCURRED
using 2008 Global catalogs?
KB17325-Issues with the BlackBerry Enterprise Server when using a Windows Server 2008 Global Catalog Server - NSPI Bind Limit exceeded
Unable to log on to BAS when running a mixed domain environment
KB18186-Unable to log in to the BlackBerry Administration Service web console when running a mixed Windows Server 2003 and 2008 domain controller environment